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DSPE-PEG-Biotin (DSPE-PEG-BIO) is a linear heterobifunctional PEGylation reagent with a DSPE phospholipid and a biotin. It is
a useful self-assembling reagent to prepare grafted or PEGylated liposome or micelle while also providing an biotin group for
binding to avidin or streptavidin.
It is often used in targeted drug delivery with the lipid bilayer to improve drug solubility, the PEG to provide stealth property, extend
circulation half-life and reduce non-specific protein binding or cell adhesion, and the biotin group to non-covalently bind to
targeting molecules including antibody, aptamer, protein, and peptide.