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Tritylthiol terminated poly-L-Glutamic acid (pGlu-tritylthiol, Tritylthiol-pGlu, Trt-SH-PGlu, pGlu-Trt-SH) is a negatively charged synthetic polyamino acid terminated with trityl protected SH. It is a crystalline solid soluble in water. Applications for Tritylthiol-poly-L-glutamic acid include the conjugation to active molecules for improved activities and the layer-by-layer deposition techniques for surface coating.
Tritylthiol Poly-L-glutamic acid can be offered in form of sodium salts. Trityl group can be easily removed by TFA to obtain free SH. SH-terminated polymers were used to selectively react with maleimide and transition metal surface including gold, silver, etc.