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Biotinylated poly-L-lysine hydrochloride or Poly-L-lysine hydrochloride biotin (PLL-biotin) is a positively charged synthetic
polyamino acid having one HCl per lysine unit and biotin on the N-terminal. It is a crystalline solid soluble in water. Applications for
poly-L-lysine hydrobromide include the promotion of cell adhesion to solid substrates for culture dishes or slides, the conjugation
to active molecules for improved activities, the layer-by-layer deposition techniques, and the complexation with nucleic acids for
Biotins (BIO)-functionalized polymers can bind to streptavidin and avidin with high affinity and specificity.